The MPS Diseases

The mucopolysaccharidoses (MPS) family is a group of inherited diseases, each caused by accumulation of various glycosaminoglycans (GAGs) in the lysosomes. The exact GAGs that accumulate are different in each case.

MPS diseases include seven sub-types: MPS I, MPS II, MPS III, MPS IV, MPS VI, MPS VII, and MPS IX. Although each of the individual MPS disorders can cause a variety of different symptoms, many of the diseases share similar symptoms, such as corneal clouding, short stature, joint stiffness, speech and hearing problems, hernias, runny nose, and heart problems.